Reumadagarna i Uppsala 2018 Program och abstracts

8210

Inflammatorisk tarmsjukdom IBD och biologiska läkemedel

Relationship between serum infliximab trough levels and endoscopic activities in patients with Crohn's disease under scheduled maintenance treatment. The role of trough serum infliximab (s-IFX) and antibodies toward IFX (ATI) during maintenance treatment remains unclear in children. The aim of the present study was to investigate trough s-IFX and ATI to identify any correlation with inflammatory activity and clinical response in a pediatric inflammatory bowel disease (IBD) cohort. Relationship between serum trough infliximab levels, pretreatment C reactive protein levels, and clinical response to infliximab treatment in patients with rheumatoid arthritis. Ann Rheum Dis. 2005; 64 : 704-707 Background: There is some evidence in adults that higher serum infliximab (IFX) levels are needed to adequately treat fistulizing perianal Crohn's disease (CD). However, data in children are lacking.

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The median IFX14 level was 5.1 μg/mL in patients in SDR22 versus 3.0 μg/mL in patients not in SDR (P = 0.04). consecutive infliximab serum trough levels and anti-infliximab antibodies in patients with stable DAS28 and treatment was analysed with Spearman correlation and kappa-analysis. Results: 147 patients with a mean disease duration of 11 years (sd7) and DAS28 of 3.5 (sd1.3) at baseline were The aim of this study was to identify genetic variants associated with trough serum anti‐TNF levels and whether these variants are differential markers for infliximab and adalimumab. Methods We included 154 children (age < 18 years) from 17 hospitals who had been diagnosed with IBD and actively treated with infliximab or adalimumab. For infliximab trough concentrations 5.0 mcg/mL or less, testing for antibodies to infliximab (ATI) is suggested.

Room temperature: 48 hours ; Refrigerated by immunoassays. RESULTS: Endoscopic activity negatively correlated with serum IFX trough levels (Spearman's rank correlation coefficient (ρ) = -0.54, P < 0.0001) and serum albumin levels (ρ = -0.46, P < 0.0001), and positively correlated with CRP (C-reactive protein) levels (ρ = 0.55, P < 0.0001), ESR (erythrocyte Higher Postinduction Infliximab Serum Trough Levels Are Associated With Healing of Fistulizing Perianal Crohn's Disease in Children Higher trough IFX levels are associated with healing of fistulizing perianal CD. Higher trough IFX levels are associated with healing of fistulizing perianal CD. Detectable trough serum infliximab was present in only 39% of 115 patients after a median interval from the baseline infusion of 10.7 months or within 8 weeks of cessation of infliximab administration in the case of treatment failure. Relationship between serum trough infliximab levels, pretreatment C reactive protein levels, and clinical response to infliximab treatment in patients with rheumatoid arthritis.

Antikroppar mot IFX - NanoPDF

body weight, serum albumin levels, loss of drug through leaking into the stool,  8 okt. 2020 — Att mäta dalvärdet av infliximab i serum som mått på hur Infliximab trough levels may predict sustained response to infliximab in patients with  Anti-TNF agent drug survival in patients with IBD Infliximab point-of-care assay dedicated for therapeutic drug monitoring of serum infliximab trough levels.

Serum infliximab trough levels

Reumadagarna 2015 - Svensk Reumatologisk Förening

Serum infliximab trough levels

Imaeda H, Bamba S, Takahashi K, et al: Relationship between serum infliximab trough levels and endoscopic activities in patients with Crohn's disease under scheduled maintenance treatment. J Gastroenterol. 2014 Apr;49(4):674-682 6.

Serum infliximab trough levels

Infliximab dose increased by 50 mg or 100 mg. Trough levels of infliximab of greater than 10 micrograms/ml on at least 2 occasions. Infliximab dose reduced. Trough drug level between 5 micrograms/ml and … To analyze whether serum Infliximab trough levels (ITL) at the induction phase are associated with Infliximab clearance and clinical outcomes at week (W) 54 and to investigate the association with immunogenicity development. Trough serum levels of infliximab corresponded with the magnitude of ACR response. There was no significant difference in observed ACR20 response rates across the infliximab treatment groups, however, ACR50 and ACR70 response rates increased with increased serum trough levels.
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Layout table for additonal information Relationship between serum trough infliximab levels, serum antibodies to infliximab, serum albumin levels and clinical response to infliximab treatment in patients with inflammatory bowel diseases Karin Malickova1, Ivana Janatkova1, Helena Brodska1, Dana Duricova2, Martin Bortlik2, Tomas Zima1 and Milan Lukas1,2 Cornillie F, Hanauer SB, Diamond RH, et al. Postinduction serum infliximab trough level and decrease of C-reactive protein level are associated with durable sustained response to infliximab: a retrospective analysis of the ACCENT I trial. Gut. 2014;63(11):1721-1727. 12. Ordás I, Feagan BG, Sandborn WJ. Trough level quantitation for evaluation of patients with loss of response to infliximab and infliximab-dyyb Clinical Information Infliximab (Remicade, Renflexis, Inflectra) is a chimeric immunoglobulin (IgG1 kappa) targeting tumor necrosis factor-alpha (TNF-a), and it is currently FDA-approved for the treatment of multiple inflammatory conditions.

Objective: To investigate the relationship between serum trough infliximab levels and clinical response to infliximab treatment in patients with rheumatoid arthritis (RA).
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Egenskaper hos biologiska läkemedel och terapeutiska

side effects, or hypersensitivity and serum TNF-a, IFX trough levels, and ATI concentrations. Measurement of serum TNF-a, IFX trough levels, and ATI Enzyme-linked immunosorbent assay (ELISA) was ap-plied to determine the serum levels of TNF-a, infliximab trough levels, and ATI. Blood samples were obtained pri-or to application of IFX infusion. Conclusions: The trough level 4.1 μg/mL may serve as cut-off for clinical remission. Drug trough levels decreased during treatment and almost all patients with undetectable s-infliximab and monotherapy had developed antibodies against the drug. © 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

Sveriges lantbruksuniversitet - Primo - SLU-biblioteket

Low infliximab serum trough levels and anti-infliximab antibodies are prevalent in rheumatoid arthritis patients treated with infliximab in daily clinical practice: results of an observational cohort study. BMC Musculoskelet Disord 2012; 13: 184., 26 Ben-Horin S, Yavzori M, Katz L, et al. 2015-05-12 · Patients receiving maintenance infliximab for Crohn disease could benefit from an infliximab trough level, followed by dosage adjustment for levels outside the range of 3 to 7 µg/mL. Once the target level has been achieved, little is gained by additional trough level measurements during stable, continuing maintenance therapy.

5 – 8 Available data suggest a relationship between clinical efficacy and serum trough levels of infliximab, while detection of antibodies to infliximab (ATI) as such seems to be less relevant parameter. 6, 9 Concomitant 19. Steenholdt C, Bendtzen K, Brynskov J, et al. Changes in serum trough levels of infliximab during treatment intensification but not in anti-infliximab antibody detection are associated with clinical outcomes after therapeutic failure in Crohn's disease. J Crohns Colitis 2015; 9:238–245. CT-P13 is a biosimilar drug of reference infliximab and is approved in some countries for use in some indications for which reference infliximab is ap… The distribution of serum infliximab (s-IFX) levels in 92 serum samples from 44 maintenance-treated pediatric IBD patients (one to four samples per patient) obtained immediately before the next scheduled infusion.